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Dr. Cantrell studies the evolution and function of mammalian
retrotransposons, particularly LINE-1 elements, and the effects of
these elements on genome evolution. In one project, he is exploring
the potential connection between extinction of LINE-1 activity and an
unprecedented amplification of an endogenous retrovirus family. He has
also initiated studies which address the surprising hypothesis that
LINE-1 elements may be involved in X chromosome inactivation in
mammals. |